Translational research in pulmonary hypertension: challenge and opportunity.
نویسندگان
چکیده
The first World Health Organization conference on pulmonary hypertension, held in 1971 in Geneva, Switzerland [2], had been convened to investigate the first drug-induced epidemic of so-called ‘‘primary’’ pulmonary hypertension. The clinicians had noted an unusual increase in the number of patients with often fatal pre-capillary pulmonary hypertension and, by connecting the dots, they identified the drug menocil (aminorex fumarate) as the cause of the outbreak. This first epidemic of anorexigen drug-induced pulmonary hypertension moved the ‘‘lesser or small circulation’’ [3] into the visual field of cardiologists and pulmonologists. From the perspective of today’s knowledge base a contemporary statement from Kenneth Moser is of historical interest: ‘‘The key historical event was the labeling of this vascular bed as the lesser circulation. Presumably, this description was not used in the pejorative sense; but it seems to have operated in that way, intentionally or not. Who would deign to study the lesser circulation when one could attack questions about the ‘‘greater circulation’’? Furthermore, was not the lesser circulation simply a passive system of pipes leading from right ventricle to left atrium, where the really important events would occur? Of course, along the way, the blood perfusing these passive conduits did participate in gas exchange, but that was a ‘‘pulmonary’’ not a ‘‘hemodynamic’’ event. Which brings us to the political problems experienced by the pulmonary vascular bed; namely, under which aegis does concern with this bed properly fall?’’ [3].
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عنوان ژورنال:
- The European respiratory journal
دوره 43 2 شماره
صفحات -
تاریخ انتشار 2014